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Breast
General Information
Study Name:
A221505 – Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
Age Group:
Adult
Protocol Number:
NCT03414970
Background Information:
This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells that remain after surgery and have fewer side effects.
Offered at:
Inova Schar Cancer Institute
8081 Innovation Park Drive
Fairfax, VA 22031
A department of Inova Fairfax Hospital
Eligibility Information
Inclusion:
Participant has/had histologically confirmed invasive carcinoma of the breast
No prior radiation therapy to the chest, neck or axilla
No active collagen vascular diseases, such as: systemic lupus erythematous, scleroderma, or dermatomyositis
Participant must have undergone immediate reconstruction at the time of mastectomy or be planning to undergo reconstruction within 8 months after radiation
Additional eligibility in protocol
Ineligibility Information
Exclusion:
History of prior or concurrent contralateral invasive breast cancer; benign breast disease, LCIS or DCIS of contralateral breast
Positive inked histologic margins from mastectomy pathology (no invasive cells at margin)
For patients with diabetes, hemoglobin A1C test must have been performed =< 90 days prior to registration
Additional exclusions in protocol
Contact Information
Contact Name:
Breast Cancer Research Team
Contact Phone:
571-472-0629
Contact Email:
breastcancerresearch@inova.org